Article

Nuclear genetic modulation of tissue-specific mitochondrial RNA processing contributes to common disease risk

2025-08-26

Abstract excerpt

Mitochondrial dysfunction is implicated in many common human diseases, yet it remains unclear whether it plays a primary causal role in pathogenesis or arises as a consequence disease-associated change. Moreover, the tissue-specific manifestation of mitochondrial disorders remains poorly understood, despite mitochondria being present in nearly all cell types. To address these questions, we leveraged over 15,000 RN...

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Literature Corpus work: ffacb8d3-6119-5687-b52c-bef1064162dd
DOI: 10.1101/2025.08.22.25334213

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