Article

DTT-Induced Transcriptome Profiling Reveals Divergent ER Proteostasis and Stress-Adaptation Programs in CHO-S and Apoptosis-Resistant CHO-4BGD Producer Cell Lines

2026-07-14

Abstract excerpt

Chinese hamster ovary (CHO) producer cells differ in their capacity to accommodate secretory and endoplasmic reticulum (ER) stress, but how engineered survival backgrounds shape ER-proteostasis responses remains poorly understood. We compared 24-h dithiothreitol (DTT)-induced reductive ER stress responses in two clonal producers: CHO-S-derived HB8 secreting human chorionic gonadotropin and apoptosis-resistant CHO-...

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Literature Corpus work: 005cbe5d-a7d0-588f-9cae-881ce4d1a67d
DOI: 10.20944/preprints202607.0946.v1

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DTT-Induced Transcriptome Profiling Reveals Divergent ER Proteostasis and Stress-Adaptation Programs in CHO-S and Apoptosis-Resistant CHO-4BGD Producer Cell LinesDOI 10.20944/preprints202607.0946.v1Read

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