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Article

Mapping the molecular basis for growth related phenotypes in industrial producer CHO cell lines using differential proteomic analysis.

BMC biotechnology - 23 Jul 2021

Bryan Laura, Henry Michael, Kelly Ronan M, Frye Christopher C, Osborne Matthew D, Clynes Martin, Meleady Paula

Abstract excerpt

BACKGROUND: The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant protein yields, reduce host cell impurities for downstream processing and reduce the cost of goods. In this study we implemented label-free LC-MS/MS proteomic profiling of IgG4 producing CHO cell lines...

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Identifiers

PMID: 34301236
DOI: 10.1186/s12896-021-00704-8
PMCID: PMC8305936

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