Article

Redirecting resistance evolution in <i> BRAF <sup>V600</sup> </i> melanoma by inhibition of the peroxiredoxin-thioredoxin system

2025-03-13

Abstract excerpt

<h4>Summary</h4> Drug-tolerant persister cells (DTPs) exhibit remarkable cell state heterogeneity and phenotypic evolvability. However, the central question of how DTPs epigenetically coordinate their metabolic flexibility to adapt early to therapeutic stress remains unanswered. We have recently shown that the histone demethylase KDM5B, which is intrinsically expressed in differentiated melanoma DTPs, reprograms...

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Literature Corpus work: 80645b9f-6f18-563f-b2cd-b2c687f962e6
DOI: 10.1101/2025.03.10.641595

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