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SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

1 Sept 2019

Abstract excerpt

Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senescence-associated secretory phenotype (SASP) that participates in several age-related diseases. Using stable isotope labeling with amino acids (SILACs) and cultured cells, we identify 343 SASP proteins that senescent human fibroblasts secrete at 2-fold or higher levels compared with quiescent cell counterparts....

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PMID: 31553904
DOI: 10.1016/j.celrep.2019.08.049

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