Article

Mechanistic insights of radiation-induced endothelial senescence impelling glioblastoma genomic instability at relapse

2021-12-14

Abstract excerpt

Despite aggressive clinical protocol, all glioblastoma (GBM) recur at the initial site within the irradiated peritumoral microenvironment. Whereas irradiated microenvironment has been recently proposed to accelerate GBM relapse, molecular and cellular mechanisms remain unknown. Here, using relevant in vitro and in vivo models, we decipher how radiation-induced endothelial senescence drives the emergence of aggre...

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Literature Corpus work: bf552705-971e-5a2d-9e9e-b9d0a926bf98
DOI: 10.1101/2021.12.13.472364

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