Article

The Senescence-Polyploid Giant Cancer Cells-Polyamine Axis: A Pharmacological Nexus Driving Angiogenesis and Drug Resistance in Cancer

2026-01-23

Abstract excerpt

Angiogenesis is a physiological process that facilitates malignancy and remains a key feature of cancer biology. Anti-angiogenic therapies targeting the VEGF pathway initially showed clinical promise. However, their long-term efficacy has been limited by tumour recurrence and complex resistance mechanisms. These failures continue to reveal significant conceptual gaps in understanding angiogenesis as a flexible, ad...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e869950e-6002-5f8b-9694-aebbf7a1f3cc
DOI: 10.22541/au.176916440.02425728/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Senescence-Polyploid Giant Cancer Cells-Polyamine Axis: A Pharmacological Nexus Driving Angiogenesis and Drug Resistance in CancerDOI 10.22541/au.176916440.02425728/v1Read

Senescence in polyploid giant cancer cells: A road that leads to chemoresistance.Semantic proximity Read

Oncogene inactivation-induced senescence facilitates tumor relapseSemantic proximity Read

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotypeSemantic proximity Read

Bizarre giant cells in human angiosarcoma exhibit chemoresistance and contribute to poor survival outcomesSemantic proximity Read

Synchronizing Cancer Research Worldwide, a Way of Overcoming Resistance to Anti-angiogenic DrugsSemantic proximity Read

A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposureSemantic proximity Read

Human cell polyploidization: The good and the evilSemantic proximity Read

The life cycle of polyploid giant cancer cells and dormancy in cancer: Opportunities for novel therapeutic interventionsSemantic proximity Read

The HES1-SOD1 Antagonism Shapes Senescence Heterogeneity and Impacts Metastatic Relapse of Circulating Tumor CellsSemantic proximity Read

The variant senescence-associated secretory phenotype induced by centrosome amplification constitutes a pathway that activates hypoxia-inducible factor-1α.Semantic proximity Read

Phenotyping and clinical utility of phagocytic polyploid giant cancer macrophages in blood.Semantic proximity Read

A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal.Semantic proximity Read