Article
Molecular definition of a chromosome 9p21 germ-line deletion in a woman with multiple melanomas and a plexiform neurofibroma: implications for 9p tumor-suppressor gene(s).
American journal of human genetics - 1 Jul 1993
Petty E M, Gibson L H, Fountain J W, Bolognia J L, Yang-Feng T L, Housman D E, Bale A E
Abstract excerpt
Cutaneous malignant melanoma (CMM) is often familial, but the mode of inheritance and the chromosomal location of melanoma susceptibility locus are controversial. Identification of a 34-year-old woman with eight primary malignant melanomas, multiple atypical moles, and a de novo constitutional cytogenetic rearrangement involving chromosomes 5p and 9p suggested the presence of a melanoma predisposition gene at one...
Topics
- Adult
- Cell Line
- Chromosome Deletion
- Chromosomes, Human, Pair 5
- Chromosomes, Human, Pair 9
- Electrophoresis, Gel, Pulsed-Field
- Female
- Genetic Predisposition to Disease
- Humans
- In Situ Hybridization, Fluorescence
- Melanoma
- Neoplasms, Multiple Primary