Article
Effects of substitution of Val for Leu11 of ovine angiotensinogen on renin activity.
Bioscience, biotechnology, and biochemistry - 1 Nov 1998
Inui Y, Orihashi T, Okada E, Nakagawa T, Ebihara A, Suzuki F, Nakamura Y
Abstract excerpt
A mutant angiotensinogen, L11V, in which Val11 was substituted for Leu11 of ovine angiotensinogen was prepared to have the same scissile peptide bond as the human one. The mutation didn't vary Km and kcat of human renin for the ovine substrate, but decreased those of rat renin to one half and one fortieth, respectively. Distances between the P1' subsite of angiotensinogens and the 224th (human renin numbering)...
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