Effects of substitution of Val for Leu11 of ovine angiotensinogen on renin activity.

doi:10.1271/bbb.62.2267

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Article

Effects of substitution of Val for Leu11 of ovine angiotensinogen on renin activity.

Bioscience, biotechnology, and biochemistry - 1 Nov 1998

Inui Y, Orihashi T, Okada E, Nakagawa T, Ebihara A, Suzuki F, Nakamura Y

Abstract excerpt

A mutant angiotensinogen, L11V, in which Val11 was substituted for Leu11 of ovine angiotensinogen was prepared to have the same scissile peptide bond as the human one. The mutation didn't vary Km and kcat of human renin for the ovine substrate, but decreased those of rat renin to one half and one...

Topics

Amino Acid Sequence
Angiotensin II
Animals
Base Sequence
Humans
Leucine
Molecular Sequence Data
Mutation
Rats
Renin
Sheep
Species Specificity
Valine

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