Article
Substrate specificities of porcine and bovine enteropeptidases toward the peptide Val-(Asp)4-Lys-Ile-Val-Gly and its analogs.
Bioscience, biotechnology, and biochemistry - 1 Mar 2008
Kim Yong-Tae, Nishii Wataru, Matsushima Masashi, Inoue Hideshi, Ito Hisashi, Park Sun Joo, Takahashi Kenji
Abstract excerpt
The substrate specificities of porcine and bovine enteropeptidases were investigated using the peptide Val-(Asp)(4)-Lys-Ile-Val-Gly and its various analogs with mutations in the (Asp)(4)-Lys sequence as substrates. The results indicated that in addition to P1 Lys, P2 Asp in the substrates is most important, that P3 Asp is additionally important, and that P5 Asp contributes somewhat to the susceptibility, and that...
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