Article
A Mutation of Angiotensinogen in a Patient with Preeclampsia Leads to Altered Kinetics of the Renin-Angiotensin System
1 May 1995
Abstract excerpt
Angiotensinogen exhibits genetic linkage to and association with essential hypertension and preeclampsia, a common hypertensive disorder of pregnancy; however, the polymorphisms detected thus far provide no functional clues. In a preeclamptic patient, we have identified a mutation leading to the replacement of leucine by phenylalanine at position 10 of mature angiotensinogen (L10F), the site of renin cleavage....
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