Article
Roles of His9 (P2 subsite) and His13 (P3' subsite) in angiotensinogen for catalytic reaction of renin.
International journal of molecular medicine - 1 Jul 2005
Nabi A H M Nurun, Uddin Mohammad Nasir, Nakagawa Tsutomu, Orihashi Takenori, Ebihara Akio, Iwasawa Atsushi, Nakamura Yukio, Suzuki Fumiaki
Abstract excerpt
Roles of His9 (P2) and His13 (P3') of angiotensinogen for the catalytic reaction of renin were investigated using purified recombinant ovine angiotensinogen and its mutants H9Q and H13Q. The pH depended reaction of human renin with angiotensinogens of wild-type, H9Q and H13Q showed peaks at pH 6.5 and 8.5, but the altitude of each peak was different. The Vmax of the reaction between H9Q and H13Q with human renin...
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