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Article

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

12 Apr 1994

Abstract excerpt

The Cl- secretory pathway that is defective in cystic fibrosis (CF) can be bypassed by an alternative pathway for Cl- transport that is activated by extracellular nucleotides. Accordingly, the P2 receptor that mediates this effect is a therapeutic target for improving Cl- secretion in CF patients. In this paper, we report the sequence and functional expression of a cDNA cloned from human airway epithelial...

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Identifiers

PMID: 8159738
DOI: 10.1073/pnas.91.8.3275

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Source receipt: pubmed, retrieved 7 Sept 2026.

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