Stimulation by alkylxanthines of chloride efflux in CFPAC-1 cells does not involve A1 adenosine receptors.

doi:10.1021/bi00028a018

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Article

Stimulation by alkylxanthines of chloride efflux in CFPAC-1 cells does not involve A1 adenosine receptors.

Biochemistry - 18 Jul 1995

Jacobson K A, Guay-Broder C, van Galen P J, Gallo-Rodriguez C, Melman N, Jacobson M A, Eidelman O, Pollard H B

Abstract excerpt

A series of 8-substituted derivatives of 1,3,7-alkylxanthines was synthesized as potential activators of chloride efflux from a human epithelial cell line (CFPAC) expressing the cystic fibrosis transmembrane regulator (CFTR) delta F508 mutation. Their interactions with rat brain A1 and A2a receptors were also studied in radioligand binding experiments. Substitution was varied at the xanthine 1-, 3-, 7- and...

Topics

Animals
Binding Sites
Cell Line
Chlorides
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Humans
In Vitro Techniques
Ion Transport
Kinetics
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Purinergic P1 Receptor Antagonists

Rats

Receptors, Purinergic P1

Structure-Activity Relationship

Xanthines

Source

Open in PubMed

Identifiers

PMID: 7542477
DOI: 10.1021/bi00028a018

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7542477-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Stimulation by alkylxanthines of chloride efflux in CFPAC-1 cells does not involve A1 adenosine receptors.PMID 7542477Read ↗

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