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Article

Stimulation by alkylxanthines of chloride efflux in CFPAC-1 cells does not involve A1 adenosine receptors.

Biochemistry - 18 Jul 1995

Jacobson K A, Guay-Broder C, van Galen P J, Gallo-Rodriguez C, Melman N, Jacobson M A, Eidelman O, Pollard H B

Abstract excerpt

A series of 8-substituted derivatives of 1,3,7-alkylxanthines was synthesized as potential activators of chloride efflux from a human epithelial cell line (CFPAC) expressing the cystic fibrosis transmembrane regulator (CFTR) delta F508 mutation. Their interactions with rat brain A1 and A2a receptors were also studied in radioligand binding experiments. Substitution was varied at the xanthine 1-, 3-, 7- and...

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Identifiers

PMID: 7542477
DOI: 10.1021/bi00028a018

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Stimulation by alkylxanthines of chloride efflux in CFPAC-1 cells does not involve A1 adenosine receptors.PMID 7542477Read ↗

A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells.Semantic proximity Read ↗

A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator delta F508 mutation.Semantic proximity Read ↗

Adenosine and its nucleotides activate wild-type and R117H CFTR through an A2B receptor-coupled pathway.Semantic proximity Read ↗

Stimulation of chloride secretion by P1 purinoceptor agonists in cystic fibrosis phenotype airway epithelial cell line CFPEo-.Semantic proximity Read ↗

Activation of deltaF508 CFTR in a cystic fibrosis respiratory epithelial cell line by 4-phenylbutyrate, genistein and CPX.Semantic proximity Read ↗

Delta F508-CFTR channels: kinetics, activation by forskolin, and potentiation by xanthines.Semantic proximity Read ↗

Potentiation of ATP-induced Ca2+ mobilisation in human retinal pigment epithelial cells.Semantic proximity Read ↗

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.Semantic proximity Read ↗

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