Article
A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1992
Eidelman O, Guay-Broder C, van Galen P J, Jacobson K A, Fox C, Turner R J, Cabantchik Z I, Pollard H B
Abstract excerpt
A1 adenosine-receptor-antagonist drugs such as 8-cyclopentyl-1,3-dipropylxanthine (CPX) and xanthine amine congener (XAC) are found to activate the efflux of 36Cl- from CFPAC cells. These cells are a pancreatic adenocarcinoma cell line derived from a cystic fibrosis (CF) patient homozygous for th...
Topics
- 2-Chloroadenosine
- Adenocarcinoma
- Adenosine
- Cell Line
- Chlorides
- Chromosome Deletion
- Colonic Neoplasms
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Genotype
- Humans
- Kinetics
- Membrane Proteins
- Mutation
- Pancreatic Neoplasms