Stimulation of chloride secretion by P1 purinoceptor agonists in cystic fibrosis phenotype airway epithelial cell line CFPEo-.

doi:10.1111/j.1476-5381.1994.tb13047.x

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Article

Stimulation of chloride secretion by P1 purinoceptor agonists in cystic fibrosis phenotype airway epithelial cell line CFPEo-.

British journal of pharmacology - 1 May 1994

Chao A C, Zifferblatt J B, Wagner J A, Dong Y J, Gruenert D C, Gardner P

Abstract excerpt

1. P1 purinoceptor agonists like adenosine have been shown to stimulate Cl- transport in secretory epithelia. In the present study, we investigated whether P1 agonist-induced Cl- secretion is preserved in cystic fibrosis airway epithelium and which signalling mechanism is involved. The effects of...

Topics

Adenine Nucleotides
Adenosine
Calcium
Cell Line
Chloride Channels
Chlorides
Cystic Fibrosis
Electrophysiology
Epithelium
Humans
Iodine
Iodine Radioisotopes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Purinergic P1 Receptor Antagonists

Receptors, Purinergic P1

Signal Transduction

Spectrometry, Fluorescence

Theobromine

Source

Open in PubMed Open full text

Identifiers

PMID: 8032638
DOI: 10.1111/j.1476-5381.1994.tb13047.x
PMCID: PMC1910328

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8032638-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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