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Aberrant DNA Methylation in Esophageal Squamous Cell Carcinoma and its Clinical Implications in Systemic Chemotherapy

3 Feb 2025

Abstract excerpt

Esophageal cancer is a significant global health concern, with esophageal squamous cell carcinoma being the predominant subtype in high-incidence regions like China.Despite advances in multidisciplinary treatments, the prognosis for ESCC remains poor, with systemic chemotherapy facing the challenge of drug resistance.Epigenetic alterations, particularly DNA methylation, play a crucial role in ESCC carcinogenesis...

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PMID: 39991775
DOI: 10.7150/ijms.109161

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