Article
[Homozygous deletion of p16 and p15 genes in laryngeal squamous cell carcinoma].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Feb 2002
Li Fucai, Kang Ning, Li Yinghui, He Guang, Lin Changkun, Sun Xinghe, Gao Hongming, Sun Kailai
Abstract excerpt
OBJECTIVE: To assess the relationship of homozygous deletion status of p16 (MTS1/INK4a/CDKN2A), p15(MTS2/INK4b/CDKN2B) genes and laryngeal squamous cell carcinoma(LSCC) progression. METHODS: DNA was extracted from fresh tumors. Homozygous deletion of p16 exon 2(p16E2) in 80 cases of LSCC and p15 exon 2(p15E2) in 67 cases of LSCC were detected by the polymerase chain reaction technique. RESULTS: The p16E2 deletion...
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