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Article

Aberrant p16 methylation, a possible epigenetic risk factor in familial esophageal squamous cell carcinoma.

International journal of gastrointestinal cancer - 1 Jan 2005

Abbaszadegan Mohammad Reza, Raziee Hamid Reza, Ghafarzadegan Kamran, Shakeri Mohammad Taghi, Afsharnezhad Sima, Ghavamnasiry Mohammad Reza

Abstract excerpt

AIM: Detection of methylation in the p16 gene, an inhibitor of cyclin D-dependent protein kinase, as a new tumor marker for early detection of esophageal squamous cell carcinoma (ESCC) in DNA derived from blood and serum. METHOD: A large family with clustering of ESCC was assessed in Khorasan province in northeastern Iran. The family had three histologically proven cases of ESCC in two consecutive generations and...

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Identifiers

PMID: 16227635
DOI: 10.1385/IJGC:36:1:047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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