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Aberrant DNA Methylation in Esophageal Squamous Cell Carcinoma: Biological and Clinical Implications

23 Oct 2020

Abstract excerpt

Almost all cancer cells possess multiple epigenetic abnormalities, which cooperate with genetic alterations to enable the acquisition of cancer hallmarks during tumorigenesis. As the most frequently found epigenetic change in human cancers, aberrant DNA methylation manifests at two major forms: global genomic DNA hypomethylation and locus-specific promoter region hypermethylation. It has been recognized as a...

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PMID: 33194605
DOI: 10.3389/fonc.2020.549850

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