Activation of gp130 signaling in vivo by the IL-6 super-agonist K-7/D-6 accelerates repopulation of lymphoid organs after irradiation.

doi:10.1002/(SICI)1521-4141(199901)29:01<300::AID-IMMU300>3.0.CO;2-J

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Article

Activation of gp130 signaling in vivo by the IL-6 super-agonist K-7/D-6 accelerates repopulation of lymphoid organs after irradiation.

European journal of immunology - 1 Jan 1999

Frasca D, Doria G, Barattini P, Guidi F, Salvati A L, Toniatti C, Ciliberto G

Abstract excerpt

Stimulation of the gp130 signaling pathway by IL-6 is known to contribute significantly to hematopoietic expansion in vitro, mostly in combination with other cytokines. In the present study we have investigated whether a similar effect can be observed also in vivo using short-term assays in which...

Topics

Animals
Antigens, CD
B-Lymphocytes
Bone Marrow Transplantation
Cytokine Receptor gp130
Female
Genetic Variation
Hematopoiesis
Humans
Interleukin-6
Lymphoid Tissue
Male
Membrane Glycoproteins
Mice
Mice, Inbred C57BL
Receptors, Interleukin-6
Signal Transduction
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 9933112
DOI: 10.1002/(SICI)1521-4141(199901)29:01<300::AID-IMMU300>3.0.CO;2-J

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9933112-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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