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Article

Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.

The Journal of experimental medicine - 12 Jun 2006

Sawa Shin-ichiro, Kamimura Daisuke, Jin Gui-Hua, Morikawa Hideyuki, Kamon Hokuto, Nishihara Mika, Ishihara Katsuhiko, Murakami Masaaki, Hirano Toshio

Abstract excerpt

Mice homozygous for the F759 mutation in the gp130 interleukin (IL)-6 receptor subunit have enhanced gp130-mediated signal transducer and activator of transcription (STAT)3 activation and spontaneously developed a lymphocyte-mediated rheumatoid arthritis-like joint disease. Here, we show that the development of the disease is dependent on both major histocompatibility complex (MHC) II-restricted CD4+ T cells and...

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Source

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Identifiers

PMID: 16717113
DOI: 10.1084/jem.20052187
PMCID: PMC2118324

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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