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Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation

14 Dec 2020

Abstract excerpt

Interleukin (IL)-6 is a pleiotropic cytokine involved in the regulation of hematological and immune responses. IL-6 is secreted chiefly by stromal cells, but little is known about its precise role in the homeostasis of human mesenchymal stromal cells (hMSCs) and the role it may play in hMSC-mediated immunoregulation. We studied the role of IL-6 in the biology of bone marrow derived hMSC in vitro by silencing its...

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PMID: 33318571
DOI: 10.1038/s41598-020-78864-4

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