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Article

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.

Blood - 1 May 2005

Jenkins Brendan J, Roberts Andrew W, Najdovska Meri, Grail Dianne, Ernst Matthias

Abstract excerpt

The interleukin-6 (IL-6) cytokine family plays an important role in regulating cellular responses during hematopoiesis. We report here that mice homozygous for a knock-in mutation in the IL-6 cytokine family receptor signaling subunit glycoprotein (gp) 130 (gp130(Y757F/Y757F)) that leads to gp130-dependent signal transducers and activators of transcription (STAT) 1/3 hyperactivation develop a broad spectrum of...

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Share to Mice, Mutant Strains
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15650055
DOI: 10.1182/blood-2004-09-3751

Genes

STAT3
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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