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Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells

25 Apr 2024

Abstract excerpt

The efficacy of chimeric antigen receptor (CAR)-engineered T cell therapy is suboptimal in most cancers, necessitating further improvement in their therapeutic actions. However, enhancing antitumor T cell response inevitably confers an increased risk of cytokine release syndrome associated with monocyte-derived interleukin-6 (IL-6). Thus, an approach to simultaneously enhance therapeutic efficacy and safety is...

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PMID: 38670095
DOI: 10.1016/j.xcrm.2024.101526

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