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Interleukin‐6 Trans‐Signalling in Chronic Inflammation and Cancer

25 Apr 2006

Abstract excerpt

Interleukin-6 (IL-6) is a cytokine, which plays an important role in many chronic inflammatory diseases. IL-6 belongs to a family of 10 cytokines, which all act via receptor complexes containing the cytokine receptor subunit gp130. On cells, IL-6 first binds to a specific membrane-bound IL-6R and the complex of IL-6 and IL-6R interacts with gp130 leading to signal initiation. Whereas gp130 is widely expressed...

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PMID: 16640655
DOI: 10.1111/j.1365-3083.2006.01750.x

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