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Article

Cyclic nucleotide signalling: a molecular approach to drug discovery for Alzheimer's disease

27 Oct 2005

Abstract excerpt

The EPAC (exchange protein directly activated by cAMP) proteins are GEFs (guanine nucleotide-exchange factors) that activate Rap GTPases upon binding to cAMP. The involvement of these proteins in a number of diseases, neurodegenerative, inflammatory and metabolic, has started to show how they may prove to be important targets for therapeutic intervention. We first became interested in EPAC when we discovered that...

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PMID: 16246111
DOI: 10.1042/bst20051330

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