Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate.

doi:10.1016/0304-3940(94)90014-0

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Article

Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate.

Neuroscience letters - 20 Jun 1994

Felsenstein K M, Ingalls K M, Hunihan L W, Roberts S B

Abstract excerpt

Protein phosphorylation mediated by phorbol ester stimulates secretion of the beta-amyloid precursor protein (beta-APP) in the cell culture. This increase in secretion is produced by a transient increase in cleavage to produce non-amyloidogenic protease nexin II products mediated by the alpha-sec...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Cells, Cultured
Cholinergic Antagonists
Humans
Immunoblotting
Mutation
Phenotype
Phorbol 12,13-Dibutyrate
Protein Kinase C
Sweden

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