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Article

Amyloid precursor protein processing in vivo--insights from a chemically-induced constitutive overactivation of protein kinase C in Guinea pig brain.

Current medicinal chemistry - 1 May 2003

Bigl Volker, Rossner Steffen

Abstract excerpt

Aberrant proteolytical processing of the amyloid precursor protein (APP) gives rise to beta-amyloid peptides, which form deposits characteristic for the brains of Alzheimer's disease patients. From in vitro studies, protein kinase C (PKC) is known for almost 20 years to be involved the secretory pathway of APP processing, resulting in the reduced generation of beta-amyloid peptides. However, the toxicity of...

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Source

Identifiers

PMID: 12678689
DOI: 10.2174/0929867033457692

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Amyloid precursor protein processing in vivo--insights from a chemically-induced constitutive overactivation of protein kinase C in Guinea pig brain.PMID 12678689Read ↗

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