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Article

High intracellular concentrations of amyloid-beta block nuclear translocation of phosphorylated CREB.

Journal of neurochemistry - 1 Oct 2007

Arvanitis D N, Ducatenzeiler A, Ou J N, Grodstein E, Andrews S D, Tendulkar S R, Ribeiro-da-Silva A, Szyf M, Cuello A C

Abstract excerpt

The beta-amyloid peptide (Abeta) is considered responsible for the pathogenesis of Alzheimer's disease. Despite the magnitude of reports describing a neurotoxic role of extracellular Abeta, the role for intracellular Abeta (iAbeta) has not been elucidated. We previously demonstrated that in rat pheochromocytoma cells expression of moderate levels of Abeta results in the up-regulation of phospho-extracellular...

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Identifiers

PMID: 17587310
DOI: 10.1111/j.1471-4159.2007.04704.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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