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Article

Both neuronal NO synthase and nitric oxide are required for PC12 cell differentiation: a cGMP independent pathway.

Brain research. Molecular brain research - 5 Feb 1999

Phung Y T, Bekker J M, Hallmark O G, Black S M

Abstract excerpt

PC12 cells are used as a model system to study neuronal differentiation. Nerve growth factor (NGF) triggers a differentiation pathway in PC12 cells. Neurite outgrowth (a morphological marker of differentiation) in PC12 cells is significantly reduced in the presence of the NOS inhibitor l-NAME, but not d-NAME, implicating NOS in the differentiation process. Previously we have shown that the neuronal NO synthase...

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Source

Identifiers

PMID: 9931481
DOI: 10.1016/s0169-328x(98)00315-5

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Both neuronal NO synthase and nitric oxide are required for PC12 cell differentiation: a cGMP independent pathway.PMID 9931481Read ↗

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