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Article

Implication of nitric oxide in NGF-induced cell differentiation: differences between neuronal and beta cells.

Journal of neuroendocrinology - 1 Nov 1997

Fayad W, Czernichow P, Scharfmann R

Abstract excerpt

Both pancreatic beta cells (insulin-secreting cells) and neuronal cells express functional receptors for nerve growth factor. However, while the effect of nerve growth factor on neuronal differentiation is well known, its role on pancreatic beta cells is not established. It has been demonstrated that in PC12 cells, a well characterized NGF-responsive cell line, NGF increases the production of nitric oxide by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9419831
DOI: 10.1046/j.1365-2826.1997.00640.x

Genes

INS
NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Implication of nitric oxide in NGF-induced cell differentiation: differences between neuronal and beta cells.PMID 9419831Read ↗

Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells.Semantic proximity Read ↗

Both neuronal NO synthase and nitric oxide are required for PC12 cell differentiation: a cGMP independent pathway.Semantic proximity Read ↗

Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons.Semantic proximity Read ↗

Growth factor signals in neural cells: coherent patterns of interaction control multiple levels of molecular and phenotypic responses.Semantic proximity Read ↗

Differentiation of cultured neuroblastoma induced by staurosporine and cyclic AMP: methods for assessing a neuronal phenotype.Semantic proximity Read ↗

Involvement of p38 mitogen-activated protein kinase and apoptosis signal-regulating kinase-1 in nitric oxide-induced cell death in PC12 cells.Semantic proximity Read ↗

Hyperoxia induces the neuronal differentiated phenotype of PC12 cells via a sustained activity of mitogen-activated protein kinase induced by Bcl-2.Semantic proximity Read ↗

Nerve growth factor: role in growth, differentiation and controlling cancer cell developmentSemantic proximity Read ↗

Hypoxia-induced cell death and changes in hypoxia-inducible factor-1 activity in PC12 cells upon exposure to nerve growth factor.Semantic proximity Read ↗

Different outcomes of unliganded and liganded estrogen receptor-alpha on neurite outgrowth in PC12 cells.Semantic proximity Read ↗

Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.Semantic proximity Read ↗

NGF induces transient but not sustained activation of ERK in PC12 mutant cells incapable of differentiating.Semantic proximity Read ↗

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