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Article

Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells.

Nature - 4 May 1995

Peunova N, Enikolopov G

Abstract excerpt

Arrest of cell division is a prerequisite for cells to enter a program of terminal differentiation. Mitogenesis and cytostasis of neuronal cell precursors can be induced by the same or by different growth or trophic factors. Response of PC12 cells to nerve growth factor (NGF) involves a proliferative phase that is followed by growth arrest and differentiation. Here we present evidence that the cytostatic effect...

Topics

Amino Acid Oxidoreductases
Animals
Arginine
Cell Differentiation
Cell Division
DNA
Enzyme Induction
Mutation
NG-Nitroarginine Methyl Ester
Nerve Growth Factors
Neurites
Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nitric Oxide

Nitric Oxide Synthase

PC12 Cells

Rats

Second Messenger Systems

Source

Identifiers

PMID: 7536899
DOI: 10.1038/375068a0

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7536899-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells.PMID 7536899Read ↗

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