PC12 variants with altered ornithine decarboxylase expression patterns exhibit altered signal transduction capabilities.

doi:10.1006/excr.1995.1012

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Article

PC12 variants with altered ornithine decarboxylase expression patterns exhibit altered signal transduction capabilities.

Experimental cell research - 1 Jan 1995

Marschall L G, Feinstein S C

Abstract excerpt

Nerve growth factor (NGF) induced differentiation of primary and permanent neuronal cell cultures is accompanied by a rapid and transient induction of ornithine decarboxylase (ODC) mRNA and enzymatic activity; a similar ODC induction accompanies mitogenic effectors in many additional cell types. In an effort to assess the role of ODC activity in neuronal cell biology, we have used the ODC suicide substrate...

Topics

Animals
Bucladesine
Cell Differentiation
Drug Resistance
Eflornithine
Enzyme Induction
Epidermal Growth Factor
GAP-43 Protein
Membrane Glycoproteins
Nerve Growth Factors
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurites

Neurons

Ornithine Decarboxylase

Ornithine Decarboxylase Inhibitors

PC12 Cells

Phenotype

Proto-Oncogene Proteins c-fos

Source

Open in PubMed

Identifiers

PMID: 7813637
DOI: 10.1006/excr.1995.1012

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7813637-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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