Article
Fragile and unstable chromosomes in cancer: causes and consequences.
Trends in genetics : TIG - 1 Jun 2001
Richards R I
Abstract excerpt
Cancer cells commonly exhibit various forms of genetic instability, such as changes in chromosome copy number, translocations and point mutations in particular genes. Although transmissible change seems to be an essential part of the neoplastic process, the extent to which DNA instability is a cause rather than a consequence of cancer is unclear. Chromosomal fragile sites have been proposed to be not only...
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