Article
The stretch-activation response may be critical to the proper functioning of the mammalian heart.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 1999
Vemuri R, Lankford E B, Poetter K, Hassanzadeh S, Takeda K, Yu Z X, Ferrans V J, Epstein N D
Abstract excerpt
The "stretch-activation" response is essential to the generation of the oscillatory power required for the beating of insect wings. It has been conjectured but not previously shown that a stretch-activation response contributes to the performance of a beating heart. Here, we generated transgenic...
Topics
- Animals
- Cardiomegaly
- Fourier Analysis
- Heart
- Heart Rate
- Humans
- In Vitro Techniques
- Mice
- Mice, Transgenic
- Muscle Fibers, Skeletal
- Mutation
- Myocardial Contraction
- Myocardium
- Myosin Light Chains
- Papillary Muscles