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Article

Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2008

Palmer Bradley M, Wang Yuan, Teekakirikul Polakit, Hinson J Travis, Fatkin Diane, Strouse Stacy, Vanburen Peter, Seidman Christine E, Seidman J G, Maughan David W

Abstract excerpt

Male but not female mice carrying a single R403Q missense allele for cardiac alpha-myosin heavy chain (M-alphaMHC(R403Q/+) and F-alphaMHC(R403Q/+), respectively) develop significant hypertrophic cardiomyopathy (HCM) compared with male and female wild-type mice (M-alphaMHC(+/+) and F-alphaMHC(+/+), respectively) after approximately 30 wk of age. We tested the hypothesis that myofilament mechanical performance...

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Identifiers

PMID: 18281382
DOI: 10.1152/ajpheart.00644.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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