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Article

Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or β1-Adrenergic Stimulation.

Circulation. Heart failure - 1 May 2015

Tong Carl W, Wu Xin, Liu Yang, Rosas Paola C, Sadayappan Sakthivel, Hudmon Andy, Muthuchamy Mariappan, Powers Patricia A, Valdivia Héctor H, Moss Richard L

Abstract excerpt

BACKGROUND: Mammalian hearts exhibit positive inotropic responses to β-adrenergic stimulation as a consequence of protein kinase A-mediated phosphorylation or as a result of increased beat frequency (the Bowditch effect). Several membrane and myofibrillar proteins are phosphorylated under these conditions, but the relative contributions of these to increased contractility are not known. Phosphorylation of cardiac...

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Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiac Pacing, Artificial

Share to Cardiotonic Agents

Share to Cyclic AMP-Dependent Protein Kinases

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Source

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Identifiers

PMID: 25740838
DOI: 10.1161/CIRCHEARTFAILURE.114.001585
PMCID: PMC4439328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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