The molecular biology and pathophysiology of hypertrophic cardiomyopathy due to mutations in the beta myosin heavy chains and the essential and regulatory light chains.

doi:10.1007/978-1-4684-6039-1_13

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Article

The molecular biology and pathophysiology of hypertrophic cardiomyopathy due to mutations in the beta myosin heavy chains and the essential and regulatory light chains.

Advances in experimental medicine and biology - 1 Jan 1998

Epstein N D

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is perhaps the most common cause of inherited sudden death in otherwise healthy young individuals. There are presently seven known genes in which mutations have been shown to cause the disease. The first identified disease gene was beta myosin heavy chain (BMHC)....

Topics

Animals
Cardiomyopathy, Hypertrophic
Humans
Mice
Mice, Transgenic
Mutation
Myosin Heavy Chains
Myosin Light Chains

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