Article
Ablation of the N terminus of cardiac essential light chain promotes the super-relaxed state of myosin and counteracts hypercontractility in hypertrophic cardiomyopathy mutant mice.
The FEBS journal - 1 Sept 2020
Sitbon Yoel H, Kazmierczak Katarzyna, Liang Jingsheng, Yadav Sunil, Veerasammy Melanie, Kanashiro-Takeuchi Rosemeire M, Szczesna-Cordary Danuta
Abstract excerpt
In this study, we focus on the molecular mechanisms associated with the A57G (Ala57-to-Gly57) mutation in myosin essential light chains (ELCs), found to cause hypertrophic cardiomyopathy (HCM) in humans and in mice. Specifically, we studied the effects of A57G on the super-relaxed (SRX) state of myosin that may contribute to the hypercontractile cross-bridge behavior and ultimately lead to pathological cardiac...
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