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Article

Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathy.

American journal of physiology. Heart and circulatory physiology - 15 Aug 2013

Kazmierczak Katarzyna, Paulino Ellena C, Huang Wenrui, Muthu Priya, Liang Jingsheng, Yuan Chen-Ching, Rojas Ana I, Hare Joshua M, Szczesna-Cordary Danuta

Abstract excerpt

The functional consequences of the familial hypertrophic cardiomyopathy A57G (alanine-to-glycine) mutation in the myosin ventricular essential light chain (ELC) were assessed in vitro and in vivo using previously generated transgenic (Tg) mice expressing A57G-ELC mutant vs. wild-type (WT) of human cardiac ELC and in recombinant A57G- or WT-protein-exchanged porcine cardiac muscle strips. Compared with the Tg-WT,...

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Share to Biomechanical Phenomena
Share to Cardiomyopathy, Hypertrophic, Familial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemodynamics

Share to Myocardial Contraction

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Share to Myosin Light Chains

Share to Ventricular Function, Left

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Source

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Identifiers

PMID: 23748425
DOI: 10.1152/ajpheart.00107.2013
PMCID: PMC3891242

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