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Article

Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice.

The FEBS journal - 1 Jun 2017

Wang Li, Kazmierczak Katarzyna, Yuan Chen-Ching, Yadav Sunil, Kawai Masataka, Szczesna-Cordary Danuta

Abstract excerpt

We have investigated the physiology and mechanical profiles of skinned papillary muscle fibers from transgenic mice expressing the N47K mutation in the myosin regulatory light chain (RLC), shown to cause hypertrophic cardiomyopathy in humans. The results were compared with wild-type (WT) mice, both expressing the human ventricular RLC. Rate constants of a cross-bridge (XB) cycle were deduced from tension...

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Identifiers

PMID: 28467684
DOI: 10.1111/febs.14096
PMCID: PMC5490660

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