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Article

Effects of cardiac myosin isoform variation on myofilament function and crossbridge kinetics in transgenic rabbits.

Circulation. Heart failure - 1 Jul 2009

Suzuki Takeki, Palmer Bradley M, James Jeanne, Wang Yuan, Chen Zengyi, VanBuren Peter, Maughan David W, Robbins Jeffrey, LeWinter Martin M

Abstract excerpt

BACKGROUND: The left ventricles of both rabbits and humans express predominantly beta-myosin heavy chain (MHC). Transgenic (TG) rabbits expressing 40% alpha-MHC are protected against tachycardia-induced cardiomyopathy, but the normal amount of alpha-MHC expressed in humans is only 5% to 7% and its functional importance is questionable. This study was undertaken to identify a myofilament-based mechanism underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19808357
DOI: 10.1161/CIRCHEARTFAILURE.108.802298
PMCID: PMC2760018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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