Article
Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.
Genetics - 1 Aug 2008
Mito Erica, Mokhnatkin Janet V, Steele Molly C, Buettner Victoria L, Sommer Steve S, Manthey Glenn M, Bailis Adam M
Abstract excerpt
Defective DNA replication can result in substantial increases in the level of genome instability. In the yeast Saccharomyces cerevisiae, the pol3-t allele confers a defect in the catalytic subunit of replicative DNA polymerase delta that results in increased rates of mutagenesis, recombination, and chromosome loss, perhaps by increasing the rate of replicative polymerase failure. The translesion polymerases Pol...
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