Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.

PloS one - 1 Jan 2014

Gao Honghai, Moss Daniel L, Parke Courtney, Tatum Danielle, Lustig Arthur J

Abstract excerpt

The function of the replication clamp loaders in the semi-conservative telomere replication and their relationship to telomerase- and recombination mechanisms of telomere addition remains ambiguous. We have investigated the variant clamp loader Ctf18 RFC (Replication Factor C). To understand the role of Ctf18 at the telomere, we first investigated genetic interactions after loss of Ctf18 and TLC1 (the yeast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Checkpoint Kinase 2
Share to Chromatids
Share to Endodeoxyribonucleases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Exodeoxyribonucleases

Share to Hydroxyurea

Share to Methyl Methanesulfonate

Share to Replication Protein C

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 24533124
DOI: 10.1371/journal.pone.0088633
PMCID: PMC3923045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.PMID 24533124Read ↗

New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.Semantic proximity Read ↗

Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader.Semantic proximity Read ↗

RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.Semantic proximity Read ↗

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.Semantic proximity Read ↗

Novel connections between DNA replication, telomere homeostasis, and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae.Semantic proximity Read ↗

Telomerase Repairs Collapsed Replication Forks at Telomeres.Semantic proximity Read ↗

An mre11 mutation that promotes telomere recombination and an efficient bypass of senescence.Semantic proximity Read ↗

Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response.Semantic proximity Read ↗

Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair.Semantic proximity Read ↗

Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.Semantic proximity Read ↗

The preference for error-free or error-prone postreplication repair in Saccharomyces cerevisiae exposed to low-dose methyl methanesulfonate is cell cycle dependent.Semantic proximity Read ↗

Portrait of replication stress viewed from telomeres.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.