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Article

Divergent regulation of cardiac KCND3 potassium channel expression by the thyroid hormone receptors alpha1 and beta1.

The Journal of physiology - 15 Mar 2009

Gassanov Natig, Er Fikret, Michels Guido, Zagidullin Naufal, Brandt Mathias C, Hoppe Uta C

Abstract excerpt

The cardiac transient outward current I(to) is regulated by thyroid hormone (T3). However, it remains unclear whether T3 directly modulates underlying gene transcription and which thyroid receptor (TR) isoform might be responsible for gene transactivation. To clarify this situation, we analysed the role of T3 and its receptors alpha1 (TRalpha1) and beta1 (TRbeta1) in regulation of KCNA4, KCND2, KCND3 and KCNIP2...

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Source

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Identifiers

PMID: 19171649
DOI: 10.1113/jphysiol.2008.168385
PMCID: PMC2675000

Genes

KCND3
KCND2
KCNA4
KCNIP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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