Article
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy.
Oncogene - 14 Jan 1999
Blandino G, Levine A J, Oren M
Abstract excerpt
Many tumors overexpress mutant forms of p53. A growing number of studies suggest that the nature of a p53 mutation in a cell can impact upon cellular properties, clinical responses to therapy and prognosis of a tumor. To explore the cellular basis of these observations, experiments were designed...
Topics
- Adenocarcinoma
- Antineoplastic Agents
- Blotting, Western
- Cell Separation
- Cell Survival
- Cisplatin
- Drug Resistance, Neoplasm
- Etoposide
- Flow Cytometry
- Fluorescent Antibody Technique, Indirect
- Genes, p53
- Humans
- Lung Neoplasms
- Mutation