Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy.

Abstract excerpt

Many tumors overexpress mutant forms of p53. A growing number of studies suggest that the nature of a p53 mutation in a cell can impact upon cellular properties, clinical responses to therapy and prognosis of a tumor. To explore the cellular basis of these observations, experiments were designed to compare the properties of cells with and without p53 mutations within the same cell population. To that end, various...

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