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Article

Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.

Oncogene - 11 Jul 2002

Pugacheva Elena N, Ivanov Alexey V, Kravchenko Julia E, Kopnin Boris P, Levine Arnold J, Chumakov Peter M

Abstract excerpt

Mutated forms of p53 are often expressed in a variety of human tumors. In addition to loss of function of the p53 tumor suppressor, mutant p53s contribute to malignant process by acquisition of novel functions that enhance transformed properties of cells and resistance to anticancer therapy in vitro, and increase tumorigenecity, invasiveness and metastatic ability in vivo. Searching for genes that change...

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Identifiers

PMID: 12096336
DOI: 10.1038/sj.onc.1205704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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