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Article

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

The EMBO journal - 15 Feb 1996

Rowan S, Ludwig R L, Haupt Y, Bates S, Lu X, Oren M, Vousden K H

Abstract excerpt

The p53 tumor-suppressor gene product is frequently inactivated in malignancies by point mutation. Although most tumor-derived p53 mutants show loss of sequence specific transcriptional activation, some mutants have been identified which retain this activity. One such mutant, p53175P, is defectiv...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8631304
PMCID: PMC450281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8631304-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.PMID 8631304Read ↗

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Transcriptional activation by p53 correlates with suppression of growth but not transformation.Semantic proximity Read ↗

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Identification of a novel p53 functional domain that is necessary for efficient growth suppressionSemantic proximity Read ↗

Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses.Semantic proximity Read ↗

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages.Semantic proximity Read ↗

Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells.Semantic proximity Read ↗

Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s.Semantic proximity Read ↗

Dissecting p53 tumor suppressor functions in vivo.Semantic proximity Read ↗

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.Semantic proximity Read ↗

The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth.Semantic proximity Read ↗

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