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Article

Characterization of functional domains necessary for mutant p53 gain of function.

The Journal of biological chemistry - 7 May 2010

Yan Wensheng, Chen Xinbin

Abstract excerpt

Tumor cells, including SW480 carcinoma cells that carry a mutant p53, are addicted to the mutant for their survival and resistance to growth suppression by chemotherapeutic agents. Here, we investigated whether various classes of p53 mutants share a common property and functional domains necessary for mutant p53 gain of function. To test this, we generated SW480 cell lines in which endogenous mutant R273H/P309S...

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Identifiers

PMID: 20212049
DOI: 10.1074/jbc.M109.097253
PMCID: PMC2863234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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